Scientists have confirmed that Akkermansia muciniphila supplements improve metabolism in those having cardiovascular risks and pre-diabetes. Metabolic syndrome refers to risk factors like dyslipidemia, high BP, insulin resistance, and obesity. These may compromise cardio-metabolic health, placing people at diabetes and cardiovascular disease risks.
Estimates state that metabolic syndrome increases diabetes risks 5x times and cardiovascular disease risks 3x times. Liver, colon, pancreatic and breast cancer may also be linked to metabolic syndrome. Studies show gut bacteria to play a vital role in metabolic syndrome, with tweaking their balance a possible method of treatment.
A 2016 study found A. muciniphila to prevent diabetes and obesity levels in mice. Prof. Cani from Louvain led the study. They showed that administering pasteurized or live Amuciniphila was safe for humans. However, it wasn’t known if the benefits seen in mice can be seen in humans as well. However, now this claim has been proven true, published in Nature Medicine.
Akkermansia was given to obese or overweight participants. The study was a placebo-controlled, double-blind and randomized study, enrolling forty individuals with 32 of them finishing the study’s clinical phase. Those with metabolic syndrome and prediabetes were divided into 3 groups.
One which received Akkermansia, one which received a pasteurized version and another that got a placebo. Metabolic parameters impact was measured along with tolerability and safety. The pasteurized version showed maximum benefits as it was safe, improved insulin sensitivity, lowered cholesterol levels and inflammation markers and weight.
Metabolic health markers deteriorated in the group receiving the placebo. Professor Cano concluded that the study showed intervention to be well tolerated and safe and that A. muciniphila improved metabolism parameters.
This research also showed that pasteurized Akkermansia, when administered, reduced cardio-metabolic risks. These bacteria may be sold in a commercial form as proper dietary supplements before 2021 if these findings can be replicated in large scale studies.