Diet could have major effects on the gut microbiome, which is the population of microorganisms like bacteria that exist in the human gut. It is well known that through complicate metabolic interactions, dietary habits add to cancer prevention. More particularly, diets that are rich in fiber lower the jeopardy of developing specific cancers like CRC (colorectal cancer). Although such diets are a useful means of preventing cancer, their potential roles in cancer development and treatment stay poorly understood. A group of researchers from the LCSB (Luxembourg Centre for Systems Biomedicine) and the LSRU (Life Sciences Research Unit) at the University of Luxembourg has discovered that a combination of prebiotics, like dietary fiber and probiotics, such as specific beneficial bacteria, lowers the expression of drug resistance and pro-carcinogenic genes. The combination causes metabolic changes that impact the progress of cancer cells and might assist in treating diseases such as CRC.
So as to study diet-microbiome-host communications, the researchers worked with a rare gut-on-a-chip platform known as HuMiX (Human-Microbial X-talk), which permits the development of human intestinal cells collectively with bacteria below representative conditions. In this investigation, they studied the impacts of dietary regimens and a precise probiotic on CRC cells.
Recently, the University of Luxembourg was in news as its study stated that changed microbiome following cesarean section affects a baby’s immune system. Scientists from the LCSB have observed that during a natural birth particular bacteria from the mother’s gut are transferred to the baby and affect the baby’s immune responses. This transfer is affected in children that are born by cesarean section. Associate Professor Paul Wilmes—the head of the study—said, “This might explain why—epidemiologically stating—caesarean-born children experience more often from chronic, immune system-related diseases in comparison to babies born naturally.”